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1 edition of Note on potency of chemical carcinogens. found in the catalog.

Note on potency of chemical carcinogens.

Note on potency of chemical carcinogens.

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Published by Royal Society of Chemistry. Environment, Health and Safety Committee .
Written in English


Edition Notes

Other titlesPotency of chemical carcinogens.
ContributionsRoyal Society of Chemistry. Environment, Health and Safety Committee.
ID Numbers
Open LibraryOL20897304M

ISBN: OCLC Number: Description: pages: illustrations ; 29 cm: Contents: Ch. 1. Carcinogenic potency database / Lois Swirsky Gold [and others] --Ch. y of carcinogenic potency database by target organ / Lois Swirsky Gold, Neela B. Manley, and Thomas H. Slone --Ch. y of carcinogenic potency database by chemical / Lois Swirsky Gold, Thomas . Depending on the potential uses of the chemical, it is often considered prudent to confirm presumptive non-carcinogens, but to be willing to discard a mutagenic chemical that may not be carcinogenic, or label the chemical as a potential carcinogen in the absence of further testing.

  Today, about different chemical compounds and mixtures are known or anticipated to be human carcinogens. The great majority of human chemical carcinogens require metabolic activation to elicit. Chemical Research in Toxicology , 9 (1), DOI: /tx Masato Koreeda, Ramesh Gopalaswamy. Regio- and Stereocontrolled Synthesis of the Bay-Region anti-Diol Epoxide Metabolites of the Potent Carcinogens Benzo[a]pyrene and 7,Dimethylbenz[a]anthracene.

Carcinogen chemistry. 2. Carbon nuclear magnetic resonance spectroscopic study of the ambident carbocationic nature of iminium ions and its relevance to the aminoalkylating ability of related chemical carcinogens. Structure−Activity Relationship Studies of Chemical Mutagens and Carcinogens: Mechanistic Investigations and Prediction Approaches. Chemical Reviews , (5), DOI: /cry.


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Note on potency of chemical carcinogens Download PDF EPUB FB2

The level of risk associated with a carcinogenic agent depends on both the potency of the agent and the level of exposure to it. Carcinogenic potency can be estimated, fairly crudely, using clinical and epidemiologic data on humans or toxicologic data derived from animal cancer tests.

Potency of chemical carcinogens varies over a wide range. To assess relative potency, the committee compiled and analyzed data on over carcinogens—65 of which were naturally occurring. The data set included agents identified by IARC as having sufficient evidence of carcinogenicity in humans or animals, or by the NTP as known or reasonably anticipated to be human carcinogens.

Variation in Carcinogen Potency. The CPDB includes data on potent chemical carcinogens such as 2,3,7,8-tetraclorodibenzo-p-dioxin (TCDD), as well as less potent compounds such as DDT.

Gold et al. () noted that the TD 50 value in the CPDB for chemicals inducing tumors in rats varied by seven orders of magnitude or 10 million-fold. avoid exposure to carcinogens and other harmful chemicals of women who are pregnant, or may become pregnant. This is because the foetus is at high risk from harmful chemicals ingested by the mother.

This document is particularly concerned with the many different types of chemical carcinogens, their potency as carcinogens, the wide differences. Key words: cancer stages,carcinogenesis evaluation, chemical carcinogens, chemical carcinogenesis.

INTRODUCTION Public opinion considers cancer to be an increasingly threatening disease, affecting people of all ages. After cardiovascular diseases, it is the second cause of death amongst the global population (HuffWeisburger. Most chemical carcinogens are mutagens 2.

Most carcinogens and mutagens are strong electrophilic reactants. 3 Ionizing or ultraviolet radiation and most chemical carcinogens cause3.

Ionizing or ultraviolet radiation and most chemical carcinogens cause lesions in DNA. Defects in DNA repair capacity are associated with a high risk of cancer.

above, AFB1 was designated as a known human carcinogen (group 1) by IARC in [5]. Parenthetically, it is note-worthy that this designation was assigned in the absence of information about the prevalence of HBV infection in the populations studied. Chemical Carcinogen in Animals Suspect Human Carcinogen/Disease Linkage Determine Relation of.

In this study, we investigated the endogenous formation of the tobacco-specific oral and esophageal carcinogen N′-nitrosonornicotine (NNN) in e-cigarette users. Salivary NNN, nornicotine, and nicotine as well as urinary tobacco biomarkers, including total NNN, were analyzed in 20 e-cigarette users, 20 smokers, and 19 nonsmokers.

Cancer is often perceived as largely due to inherited defective genes. However, the biggest cause of human cancer is exposure to chemicals and indeed, the biggest contributors to the burden of human cancer (estimated to be about 90% of all cancers) are chemicals contained within tobacco smoke, the diet and the environment.

Chemical carcinogenesis is. Note: Scientific Review Panel unit risk 'reasonable estimate' = E-4(ug/m3) Note: CASRNs fitting the pattern 0-##-0 or 1-##-0 are generated for electronic database purposes only.

Alphabetically-sorted List — KNOWN AND SUSPECTED HUMAN CARCINOGENS Carcinogens Reference List Page 1 of Regulatory agencies currently rely on rodent carcinogenicity bioassay data to predict whether or not a given chemical poses a carcinogenic threat to humans.

We argue that it is always more useful to know a chemical's carcinogenic potency (with confidence limits) than to be able to say only qualitatively that it has been found to be a carcinogen.

Potency considerations (1) Response-dependent ranking of animal carcinogens (2) Dose-dependent ranking of animal carcinogens, TD50 (3) Percentage of human exposure dose/rodent potency dose (HERP) 4.

Mechanistic considerations an extensive data base (Carcinogenic Potency Database), the range of carcinogenic potency among chemicals was shown to be over 10 million-fold (Gold et.

Examples of indirect-acting carcinogens include polycyclic aromatic hydrocarbons, aromatic amines, alkyl nitrosamines, or aflatoxin B1. Most chemical carcinogens require metabolic activation to elicit a tumorigenic response.

Epigenetic carcinogens are carcinogens that do. The estimated maximum tolerated dose (EMTD) is based on a 90 day or other subchronic test, and its determination involves scientific judgment applied to the information available at the end of the test period.

How well the EMTD approximates the true MTD can be evaluated only after the bioassay. The highest dose tested HDT in a long-term rodent bioassay is usually used as the EMTD. Suspected carcinogens are classified in Category 3 and are assigned a MAK value only if neither the substance nor any of its metabolites is genotoxic.

In the Categories 4 and 5 are classified substances for which the available data are sufficient for assessment of the carcinogenic potency. Handbook of Carcinogenic Potency and Genotoxicity Databases by Lois Swirsky Gold,available at Book Depository with free delivery worldwide.

Such indices provide a quantitative measure of carcinogenic potential, which may be used to rank the relative potency of different carcinogens.

A widely used measure of potency is the TD 50 proposed by Peto et al. REGULATORY TOXICOLOGY AND PHARMACOLOGY 3, () The Ranking of Chemicals for Carcinogenic Potency' JEFFREY C. THEISS School of Public Health, University of Texas Health Science Center, Houston, Texas Received May 9, A relatively new approach to assessing the carcinogenic hazard that chemicals pose to man involves the development of criteria by which carcinogens.

Chemical Agents and Related Occupations IARC Monographs on the Evaluation of Carcinogenic Risks to Humans Volume F. IARC. ***This book was highly commended in the Public Health category of the British Medical Association's annual Medical Book Competition.*** Contents and Note. Chemical carcinogen Polycyclic hydrocarbons in tobacco smoke.

Mechanism of chemical carcinogens? HIghly reactive electrophiles that remove electrons from DNA, RNA or proteins How does the promotion step in chemical carcinogenesis affect cells?

Induces tumor proliferation in initiated cells. Is the promotion phase irreversible or reversible?agent depends on both the potency of the agent and the level of exposure to it. Carcinogenic potency can be estimated, fairly crudely, using clinical and epidemiologic data on humans or toxicologic data derived from animal cancer tests.Journal of Chemical Information and Modeling45 (4), DOI: /cin.

Romualdo Benigni. Structure−Activity Relationship Studies of Chemical Mutagens and Carcinogens: Mechanistic Investigations and Prediction Approaches. Chemical Reviews(5), DOI: /cry.